friedel-crafts acylation, electrophylic substitution reaction,reaction mechanism, application/uses, discovery, -by study everything.

 

Friedel craft acylation

 

Friedel craft acylation reaction is given by Charles friedel and james crafts in 1877.

Charles friedel : [wikipedia]

Charles friedel was a French chemist and mineralogist.

Born : 12 march 1832.

Died : 20 april 1899.

Nationality : French

Picture :

 

James crafts : [wikipedia]

James mason crafts was a American chemist . they mostly known for the friedel crafts reaction.

Born : 8 march 1839.

Died : 20 june 1917.

Nationality : American .

Picture :

Friedel crafts reaction is electrophilic aromatic substitution  reaction .

What do you mean of electrophilic aromatic substitution reaction.

Electrophylic means : electrophile (E⁺) .

Examples of electrophile :  aluminium chloride (AlCl₃) ,ferric chloride (FeCl₃) , helogens ( Cl₂ , f₂ , Br₂ , I₂ ) , boron trifluride (Bf₃) , and  hydronium ion (H₃O⁺)  also (⁺CH₃) .

Aromatic : benzene ring .

Substitution means : the replacement  of something or someone .

So basically in the friedel crafts reaction something is replaced at  particular space(in benzene ring ).

 

Friedel-crafts acylation :

Statement :

The reaction of benzene with acid chloride(R-COCl) or acid anhydride[(R-CO)₂O] in the presence of lewis acid (AlCl₃) gives ketones (eg. Aceto phenone). Reaction is known as friedel crafts acylation .

Here electrophile is a acid chloride or acid anhydride .

[R-COCl or (R-CO)₂O]

Chemical reaction :

 

Mechanism :

step -1 :

formation of electrophile :

step-2 : 

formation of product :

application or uses of friedel crafts acylation :

1. production of acetophenone :

2. production of ethyl phenyl ketone :

 

 

 

 

 

 

 

 

 

 

 

 

[અસ્તુ:]